Real Betis and Real Madrid clash as the latest round of La Liga fixtures commences. Los Blancos are hoping to extend their perfect start to the campaign at La Cartuja.

Pellegrini to recall key duo following shock Betis defeat

Manuel Pellegrini will be hoping for a response from his Real Betis side after a surprise 5-2 loss against Levante last time out. Changes are inevitable, with regulars Cucho Hernández and Pablo Fornals set to return, having been rested in that game.

Antony will continue wide on the right, while Rodrigo Riquelme will feature on the left flank once more. He has been one of the main positives for Los Verdiblancos so far this term. The 26-year-old has netted twice in three appearances.

The hosts are missing Diego Conde, Giovani Lo Celso and Aitor Ruibal due to injuries. They also have a fitness doubt over youngster Gonzalo Petit.

Real Betis predicted lineup vs Real Madrid (4-2-3-1): Valles; Bellerín, Bartra, Natan, F. García; Bernal, Roca; Antony, Fornals, Riquelme; C. Hernández.

Positive signs for Real Madrid after fast start under Mourinho

Real Madrid take a 100% record into matchday four, with José Mourinho settling quickly back into this role. His star players are already stepping up, with Kylian Mbappé registering four goals in three La Liga outings.

The Frenchman has been well supported by Jude Bellingham and Vinícius Júnior, who will both continue in Seville. Arda Güler, Denzel Dumfries and Bernardo Silva are pushing for recalls, with light rotation expected from the 4-0 win over Málaga.

Los Blancos are still missing Éder Militão, Rodrygo, Raúl Asencio, Ferland Mendy and Thiago Pitarch through injury. Aurélien Tchouaméni and Endrick are rated doubtful.

Real Madrid predicted lineup vs Real Betis (4-2-3-1): Courtois; Dumfries, Konaté, Huijsen, Cucurella; Silva, Valverde; Güler, Bellingham, Vinícius; Mbappé.

Real Betis vs Real Madrid Prediction

  • Safe Tip: Both teams to score
  • Odds: 1.53 (22Bet)
  • Correct score prediction: Real Betis 1-2 Real Madrid
  • 22Bet Booking Code: LBKQ6

Key stats:

  • All of the previous three meetings between the clubs have seen both teams find the net.
  • Real Betis have scored at least once in each of their past 13 competitive fixtures.
  • Real Madrid are averaging 3.33 goals per game so far in La Liga 2026/27.

Backing both teams to score is a safe pick here. Real Madrid’s attack has clicked under Mourinho, with four goals scored in each of their past two matches. However, there is still room for improvement at the other end of the pitch. They allowed relegation favourites Málaga to have 15 shots last time out.

Betis have enough firepower to hurt Real Madrid, but the home team’s main weakness is their defence. Following two reasonably solid opening performances, they conceded five goals against Levante, who also created five big chances across the 90 minutes.

Real Betis vs Real Madrid Prediction, Value Tip

  • Value Tip: Jude Bellingham to score a goal including substitutions
  • Odds: 2.511 (22Bet)
  • 22Bet Booking Code: KLJQ6

Backing Bellingham to score offers value at odds of 2.511. The midfielder has been in exceptional form since the start of the World Cup, which saw him net seven goals in eight appearances for England.

The 23-year-old has already scored twice in three La Liga outings this season. He’s averaging 2.7 shots per game.

Verdict: Both teams to score (1.53) — Real Betis 1-2 Real Madrid