Local rivals AC Milan and Inter will clash at San Siro this weekend in Serie A. The Nerazzurri have made a flying start to the campaign, but their recent derby record is poor.

Injury Problems Mounting but Cisse Shining for Milan

AC Milan suffered a major setback in midweek when they surprisingly lost 4-2 at home to Bologna. That was despite two goals from Alphadjo Cisse, who has netted five times across his last four appearances in all competitions.

Given his stunning form, Cisse could keep his place on Saturday. That would be at the expense of Gonçalo Ramos, who has only scored twice in nine league outings so far. Christian Pulisic and Luka Modrić are both expected to return after being rested last time out.

Matteo Gabbia, Alexis Saelemaekers, Ruben Loftus-Cheek and Samuel Chukwueze are sidelined through injury. Mario Gila and Diego Moreira are additional doubts, as is Adrien Rabiot, who has impressed with four goals and three assists in the Italian top flight this term.

AC Milan predicted lineup vs Inter (4-2-3-1): Maignan; Tomori, De Winter, Pavlović, Estupiñán; Jashari, Modrić; Hutchinson, Pulisic, Bartesaghi; Cisse.

Inter Still Going Strong Despite Martínez’s Absence

Even though they are missing Lautaro Martínez, who scored 17 goals in Serie A last season, Inter continue to get results. Their 2-0 win at Venezia on Wednesday came courtesy of two own goals.

Cristian Chivu opted to rest Nicolò Barella, Hakan Çalhanoğlu, Manuel Akanji and Djed Spence in midweek. Those four players should all return, but Luis Henrique remains sidelined. Benjamin Pavard, Curtis Jones and John Stones are also major doubts.

Without Lautaro Martínez, Marcus Thuram should lead the line, and he’s set for a competitive duel against Milan defender Strahinja Pavlović. Thuram is averaging exactly four shots per game in the league.

Inter predicted lineup vs AC Milan (3-5-2): J. Martínez; Bisseck, Akanji, Bastoni; Spence, Barella, Çalhanoğlu, Sučić, Dimarco; Thuram, Esposito.

AC Milan vs Inter Prediction

  • Safe Tip: AC Milan +1 Handicap
  • Odds: 1.392 (22Bet)
  • Correct score prediction: AC Milan 1-1 Inter
  • 22Bet Booking Code: 9FJ29

Key stats:

  • AC Milan haven’t lost any of the last seven competitive meetings.
  • Inter haven’t scored in any of the previous three Milan derbies, including a 3-0 Coppa Italia defeat in 2025.
  • Ruben Amorim’s team have only been beaten once in nine league outings this term.

AC Milan’s strong recent record in this fixture means their opponents don’t justify their status as such clear favourites. The Rossoneri have beaten their city rivals on five occasions across all competitions since their most recent defeat.

Inter have been the more convincing team overall in Serie A this season, which creates a risk when betting against them. However, that was also true last term, when they lost both derbies 1-0.

Chivu’s side have again struggled on the big stage this season, losing two of their three Champions League fixtures. Backing Milan with a +1 handicap is therefore a smart approach at 1.392.

AC Milan vs Inter Prediction, Value Tip

  • Value Tip: Under 3 goals
  • Odds: 1.8 (22Bet)
  • 22Bet Booking Code: GRM29

Inter have been solid defensively of late, conceding just twice in their past four Serie A outings. However, they also had only two shots on target against the bottom club in midweek.

Since the start of 2024, only one of the eight competitive Milan derbies has produced four or more goals. Therefore, backing under 3 goals offers value at 1.8.

Verdict: AC Milan +1 Handicap (1.392) — AC Milan 1-1 Inter.