Spain have made a 100% start to the Nations League. They are clear favourites to collect three more points against Czechia at the Estadio Carlos Tartiere.

Spain continue to fire after golden summer

After winning the 2026 World Cup, Spain have continued to look like the outstanding team in Europe during this international window. Barcelona youngsters Lamine Yamal and Pau Cubarsí were among the starters as they eased to a 4-1 win over Croatia last time out.

Yamal was replaced in the 68th minute in that game, having scored twice and assisted once. That suggests Luis de la Fuente was keen to keep his star winger fresh for this match, but changes are expected in other positions.

Nico Williams could return on the left flank, while Ferran Torres may lead the line. He has struck four goals in five Ligue 1 appearances this term for PSG. Alejandro Grimaldo, Eric García and Pedro Porro have all withdrawn from the squad due to injuries.

Spain predicted lineup vs Czechia (4-3-3): Simón; Pubill, Huijsen, Cubarsí, F. García; Rodri, Pedri, Merino; Yamal, Ferran, Williams.

Šulc ban adds to Czechia’s problems

Home defeats against Croatia and England leave Czechia firmly on course for relegation to League B. Their chances of upsetting Spain are damaged further by the suspension of Pavel Šulc, who was sent off after only 25 minutes against the Three Lions.

The visitors are coached by former Spain U21 boss Santi Denia, who will be familiar with many of the opposition players. However, his plans have also been hit by an injury to Adam Karabec on matchday two, with the 23-year-old set to miss this encounter.

Ladislav Krejčí should captain the side, and he’s got a key role to play in central defence. The Wolves man is averaging 10 clearances and seven aerial challenges won per 90 minutes in the Championship this season.

Czechia predicted lineup vs Spain (4-2-3-1): Kovář; Chaloupek, Hranáč, Krejčí, Sláma; Sadílek, Červ; Radosta, Ambros, Lingr; Hložek.

Spain vs Czechia Prediction

  • Safe Tip: Spain -1.5 Handicap
  • Odds: 1.25 (22Bet)
  • Correct score prediction: Spain 4-0 Czechia
  • 22Bet Booking Code: 56S77

Key stats:

  • Czechia are winless in five outings, losing four of them.
  • Spain are on a nine-game winning streak, including their extra-time victory in the World Cup final against Argentina.
  • La Roja have only conceded 0.43 goals per match on average in 2026.

With David Jurásek, Tomáš Vlček, Lukáš Provod and Tomáš Chorý unable to join the squad for this international break, Czechia are missing many important players. Morale in their camp was already low after a poor World Cup, which saw them collect just one point from three games.

Spain boast genuine depth in midfield and attack, with all of their key players in those areas available. They created four big chances and had 16 shots against Croatia on matchday two. At odds of 1.25, they are a safe pick to win by two or more goals again.

Spain vs Czechia Prediction, Value Tip

  • Value Tip: Lamine Yamal to score including substitutions
  • Odds: 1.885 (22Bet)
  • 22Bet Booking Code: C9777

Yamal is in fantastic form for club and country. He has registered eight goals in his previous six appearances for Barcelona, while he has been the dominant attacking player for Spain over the past week.

With three goals in two outings already in this Nations League campaign, he offers value at odds of 1.885 to score in Oviedo.

Verdict: Spain -1.5 Handicap (1.25) — Spain 4-0 Czechia