The Inter & Co Stadium will be the venue for the one-on-one MLS clash between Orlando City SC and Inter Miami, with the match kicking off at 23:30 GMT.
After four matches without a win, Orlando City SC returned to winning ways last time out when they defeated Philadelphia Union in a thrilling 2-3 in the MLS.
Orlando City had to come from behind against Philadelphia after they went behind after 12 minutes through a Mikael Uhre strike. However, they equalized in the 21st minute through Duncan McGuire.
Luis Muriel took over with a quick brace on either side of the break, with the first coming in the 41st minute and the second coming in the 46th minute.
Although Philadelphia pulled a goal back in the 66th minute through a converted Daniel Gazdag penalty, Orland City SC held on for a win, ending their winless run. They will look to retain their form and momentum when they play Inter Miami on Wednesday.
Inter Miami extended their winning run in the MLS when they won a close contest against Montreal last Sunday.
Monreal raced to a comfortable 2-0 lead by the 32nd minute, with goals by Bryce Duke and Jules-Anthony Vilsaint. However, Inter Miami demonstrated their character and fighting spirit to draw level before the break through Matias Rojas and Luis Suarez strikes.
Benjamin Cremaschi struck the winner in the 59th minute, giving Inter Miami a crucial win. They will look to extend their winning run when they play Orlando City SC.
Inter Miami has won three of its last five meetings, with Orlando City winning once and the other match ending in a draw.
Orlando City will be without their center-forward, with the 23-year-old sidelined with an ankle injury.
Due to injury, Inter Miami will be without Ian Fray, Facundio Farias, Robbie Robinson, Federico Redonod, and Jordi Alba.
Given their current red-hot form, the Inter Miami charges are the favorite heading into this match. They will win and extend their run in MLS.
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