MLS action is set for ScottsMiracle-Gro Field on September 27, as Eastern Conference playoff chasers Inter Miami travel to the Columbus Crew.

Crew Aiming for Successive Wins

Laurent Courtois’ Columbus Crew have made a reliable resumption to the season following the World Cup, reaching the final of the U.S. Open Cup.

The Crew will be chasing successive MLS wins this weekend, but it is worth noting that they have suffered six league defeats in their previous eight. Defensively, they have been weak throughout the campaign, allowing at least one goal in nine of their last ten.

The departures of Diego Rossi and Max Arfsten have impacted their attacking output. But Brais Mendez is beginning to carry that workload after scoring in back-to-back fixtures. Nicholas Hagen, Cole Mrowka, and Gonzalo Tapia are unavailable due to international commitments. Wessam Abou Ali is missing due to injury.

Columbus Crew predicted lineup vs Inter Miami (4-4-2): Schulte; Farsi, Moreira, Zawadzki, Amundsen; Mendez, Habroune, Gomes, Zaroury; Martinez, Rodriguez

Inter Stuck in Drawing Sequence

Reigning MLS champions Inter Miami have endured a challenging campaign, highlighted by the fact that Kily Gonzalez is their third manager of the season.

Inter have drawn their previous four MLS fixtures, and they have recorded just one victory in nine league events. Defensive issues have plagued their consistency in 2026, and they have allowed at least two goals in three of their last four games.

Lionel Messi is a notable player missing this weekend, as the Argentine represents his nation. German Berterame, Rodrigo De Paul, and Dayne St. Clair are also unavailable. Luis Suarez will be under pressure to make the difference in the final third after registering four goal involvements in six appearances.

Inter Miami predicted lineup vs Columbus Crew (4-3-3): Novo; Mura, Falcon, Lujan, Caicedo; Casemiro, Bright, Galarza; Segovia, Suarez, Allende

Columbus Crew vs Inter Miami Prediction

  • Safe Tip: Both Teams to Score (BTTS)
  • Odds: 1.31 (22Bet)
  • 22Bet Booking Code: ENMC4
  • Correct score prediction: Columbus Crew 2-1 Inter Miami

Key stats:

  • Columbus Crew have scored at least once in five of their last six.
  • BTTS has been a winning selection in Inter’s last eight MLS fixtures.
  • Both teams have scored in five of their six most recent head-to-heads.

Goals look to be assured when Inter Miami and Columbus Crew collide on Sunday. The hosts have scored at least once in five of their last six competitive games, while they have also allowed at least one goal in four fixtures over that same period.

Inter’s attacking strength is obvious, as no side in the MLS has scored more goals this season (63).

However, the defensive weakness typically gives rivals a chance, reflected in their failure to keep clean sheets in nine straight league matches. BTTS has also been a winning selection in five of the previous six head-to-heads.

Columbus Crew vs Inter Miami Prediction, Value Tip

  • Value Tip: Columbus Crew
  • Odds: 2.775 (22Bet)
  • 22Bet Booking Code: DRPC4

The home win is a value play this weekend based on the fact that Inter Miami will be without key stars like Messi, Berterame, and De Paul.

Even with their best players, Inter have failed to win in eight of their previous nine matches in the MLS. The Crew have looked back to somewhere near their best in recent fixtures, winning back-to-back games against Orlando City and Montreal.

Verdict: BTTS (1.31) — Columbus Crew 2-1 Inter Miami